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Transient silencing of PTEN in human CD34+ cells enhances their proliferative potential and ability to engraft immunodeficient mice
The ability to expand hematopoietic stem and progenitor cells (HSPCs) in vitro will enhance the success of a wide range of transplant-related therapies. PTEN (phosphatase and tensin homologue deleted on chromosome 10) has been implicated as a regulator of murine HSPC self-renewal but little is under...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237729/ https://ncbi.nlm.nih.gov/pubmed/22019626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.10.001 |
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