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Image-Guided Tumor-Selective Radioiodine Therapy of Liver Cancer After Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

We reported the induction of tumor-selective iodide uptake and therapeutic efficacy of (131)I in a hepatocellular carcinoma (HCC) xenograft mouse model, using novel polyplexes based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the epidermal growth factor...

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Detalhes bibliográficos
Main Authors: Klutz, Kathrin, Willhauck, Michael J., Dohmen, Christian, Wunderlich, Nathalie, Knoop, Kerstin, Zach, Christian, Senekowitsch-Schmidtke, Reingard, Gildehaus, Franz-Josef, Ziegler, Sibylle, Fürst, Sebastian, Göke, Burkhard, Wagner, Ernst, Ogris, Manfred, Spitzweg, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237693/
https://ncbi.nlm.nih.gov/pubmed/21851208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.041
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