Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

The ability of tumor cells to develop simultaneous resistance to structurally different cytotoxic drugs constitutes a major problem in cancer chemotherapy. It was previously demonstrated that multidrug-resistant Chinese hamster cell lines contain an amplified, transcriptionally active DNA sequence d...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Roninson, I B, Chin, J E, Choi, K G, Gros, P, Housman, D E, Fojo, A, Shen, D W, Gottesman, M M, Pastan, I
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1986
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323769/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3459187/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.12.4538
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