Na(+)-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

To clarify the physiological role of Na(+)-d-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(−/−) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-border membrane (BBM) via SGLT1 and GLUT2 were anal...

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Main Authors: Gorboulev, Valentin, Schürmann, Annette, Vallon, Volker, Kipp, Helmut, Jaschke, Alexander, Klessen, Dirk, Friedrich, Alexandra, Scherneck, Stephan, Rieg, Timo, Cunard, Robyn, Veyhl-Wichmann, Maike, Srinivasan, Aruna, Balen, Daniela, Breljak, Davorka, Rexhepaj, Rexhep, Parker, Helen E., Gribble, Fiona M., Reimann, Frank, Lang, Florian, Wiese, Stefan, Sabolic, Ivan, Sendtner, Michael, Koepsell, Hermann
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2012
Subjects:
Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237647/
https://ncbi.nlm.nih.gov/pubmed/22124465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1029
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