Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

Tubule-interstitial nephritis (TIN) results in decreased renal function and interstitial inflammation, which ultimately leads to fibrosis. Excessive adenine intake can cause TIN because xanthine dehydrogenase (XDH) can convert this purine into an insoluble compound, which precipitates in the tubuli....

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Autori principali: Correa-Costa, Matheus, Braga, Tarcio Teodoro, Semedo, Patricia, Hayashida, Caroline Yuri, Bechara, Luiz Roberto Grassmann, Elias, Rosa Maria, Barreto, Claudiene Rodrigues, Silva-Cunha, Claudia, Hyane, Meire Ioshie, Gonçalves, Giselle Martins, Brum, Patricia Chakur, Fujihara, Clarice, Zatz, Roberto, Pacheco-Silva, Alvaro, Zamboni, Dario S., Camara, Niels Olsen Saraiva
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237574/
https://ncbi.nlm.nih.gov/pubmed/22194975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029004
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