AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

Thioredoxin-interacting protein (TXNIP) regulates critical biological processes including inflammation, stress and apoptosis. TXNIP is upregulated by glucose and is a critical mediator of hyperglycemia-induced beta-cell apoptosis in diabetes. In contrast, the saturated long-chain fatty acid palmitat...

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Autori principali: Shaked, Maayan, Ketzinel-Gilad, Mali, Cerasi, Erol, Kaiser, Nurit, Leibowitz, Gil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237554/
https://ncbi.nlm.nih.gov/pubmed/22194917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028804
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