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Paxillin Mediates Sensing of Physical Cues and Regulates Directional Cell Motility by Controlling Lamellipodia Positioning

Physical interactions between cells and the extracellular matrix (ECM) guide directional migration by spatially controlling where cells form focal adhesions (FAs), which in turn regulate the extension of motile processes. Here we show that physical control of directional migration requires the FA sc...

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Detalhes bibliográficos
Main Authors: Sero, Julia E., Thodeti, Charles K., Mammoto, Akiko, Bakal, Chris, Thomas, Sheila, Ingber, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237434/
https://ncbi.nlm.nih.gov/pubmed/22194823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028303
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