Bimodal Regulation of FoxO3 by AKT and 14-3-3

FoxO3 is a member of FoxO family transcription factors that mediate cellular functions downstream of AKT. FoxO3 phosphorylation by AKT generates binding sites for 14-3-3, which in-turn regulates FoxO3 transcriptional activity and localization. We examine here the functional significance of AKT-FoxO3...

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Main Authors: Dobson, Melissa, Ramakrishnan, Gopalakrishnan, Ma, Stephanie, Kaplun, Ludmila, Balan, Vitaly, Fridman, Rafael, Tzivion, Guri
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237389/
https://ncbi.nlm.nih.gov/pubmed/21621563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.05.001
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