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Bimodal Regulation of FoxO3 by AKT and 14-3-3
FoxO3 is a member of FoxO family transcription factors that mediate cellular functions downstream of AKT. FoxO3 phosphorylation by AKT generates binding sites for 14-3-3, which in-turn regulates FoxO3 transcriptional activity and localization. We examine here the functional significance of AKT-FoxO3...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237389/ https://ncbi.nlm.nih.gov/pubmed/21621563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.05.001 |
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