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Mechanistic Insight into the H(2)O/D(2)O Isotope Effect in the Proton Transport of the Influenza Virus M2 Protein
The M2 proton channel is essential for the replication of the flu virus and is a known drug target. The functional mechanism of channel activation and conductance is key to both the basic biology of viral replication and the design of drugs that can withstand mutations. A quantitative model was prev...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237009/ https://ncbi.nlm.nih.gov/pubmed/22041938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-011-9402-6 |
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