A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determ...

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Autori principali: Coutinho, Mariana L., Choy, Henry A., Kelley, Melissa M., Matsunaga, James, Babbitt, Jane T., Lewis, Michael S., Aleixo, Jose Antonio G., Haake, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236721/
https://ncbi.nlm.nih.gov/pubmed/22180800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001422
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