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A Study of the α-Helical Intermediate Preceding the Aggregation of the Amino-Terminal Fragment of the β Amyloid Peptide (Aβ(1–28))

The β amyloid (Aβ) peptide aggregates to form β-rich structures that are known to trigger Alzheimer’s disease. Experiments suggest that an α-helical intermediate precedes the formation of these aggregates. However, a description at the molecular level of the α-to-β transition has not been obtained....

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Detalhes bibliográficos
Main Authors: Rojas, Ana V., Liwo, Adam, Scheraga, Harold A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236598/
https://ncbi.nlm.nih.gov/pubmed/21939202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp2050993
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