PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells

Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide (NO) synthase. Guanosine 5′-triphosphate cyclohydrolase-I (GTPCH-I) is a key limiting enzyme for BH4 synthesis. In the present in vitro study, we investigated whether peroxisome proliferator-activated receptor α (PPAR-α)...

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Detalhes bibliográficos
Main Authors: Liu, Jinbo, Lu, Changlin, Li, Fuwang, Wang, Haining, He, Liyun, Hao, Yanting, Chen, Alex F., An, Huijie, Wang, Xian, Hong, Tianpei, Wang, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236356/
https://ncbi.nlm.nih.gov/pubmed/22190909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/523520
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