Hybrid metabolic flux analysis: combining stoichiometric and statistical constraints to model the formation of complex recombinant products

BACKGROUND: Stoichiometric models constitute the basic framework for fluxome quantification in the realm of metabolic engineering. A recurrent bottleneck, however, is the establishment of consistent stoichiometric models for the synthesis of recombinant proteins or viruses. Although optimization alg...

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Autores principales: Carinhas, Nuno, Bernal, Vicente, Teixeira, Ana P, Carrondo, Manuel JT, Alves, Paula M, Oliveira, Rui
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Methodology Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236310/
https://ncbi.nlm.nih.gov/pubmed/21352531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-34
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