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Insights into the Phosphoryl Transfer Mechanism of Cyclin-dependent Protein Kinases from Ab Initio QM/MM Free-energy Studies
Phosphorylation reactions catalyzed by kinases and phosphatases play an indispensible role in cellular signaling, and their malfunctioning is implicated in many diseases. A better understanding of the catalytic mechanism will help design novel and effective mechanism-based inhibitors of these enzyme...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236095/ https://ncbi.nlm.nih.gov/pubmed/21999515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp207532s |
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