The PDL1-PD1 Axis Converts Human Th1 Cells Into Regulatory T Cells

Immune surveillance by T helper type 1 (Th1) cells is critical for the host response to tumors and infection, but also contributes to autoimmunity and graft-versus-host disease (GvHD) after transplantation. The inhibitory molecule programmed death ligand-1 (PDL1) has been shown to anergize human Th1...

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Autors principals: Amarnath, Shoba, Mangus, Courtney W., Wang, James C.M., Wei, Fang, He, Alice, Kapoor, Veena, Foley, Jason E., Massey, Paul R., Felizardo, Tania C., Riley, James L., Levine, Bruce L., June, Carl H., Medin, Jeffrey A., Fowler, Daniel H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235958/
https://ncbi.nlm.nih.gov/pubmed/22133721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003130
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