Attenuating GABA(A) Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice

Phasic dopamine (DA) transmission encodes the value of reward-predictive stimuli and influences both learning and decision-making. Altered DA signaling is associated with psychiatric conditions characterized by risky choices such as pathological gambling. These observations highlight the importance...

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Main Authors: Parker, Jones G., Wanat, Matthew J., Soden, Marta E., Ahmad, Kinza, Zweifel, Larry S., Bamford, Nigel S., Palmiter, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235504/
https://ncbi.nlm.nih.gov/pubmed/22114279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1715-11.2011
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