Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and can be Reversed by Expression of Exogenous Dsg3

Pemphigus vulgaris (PV) is an epidermal blistering disorder caused by antibodies directed against the desmosomal cadherin desmoglein-3 (Dsg3). The mechanism by which PV IgG disrupt adhesion is not fully understood. To address this issue, primary human keratinocytes and patient IgG were utilized to d...

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Detalhes bibliográficos
Main Authors: Jennings, Jean Marie, Tucker, Dana K., Kottke, Margaret D., Saito, Masataka, Delva, Emmanuella, Hanakawa, Yasushi, Amagai, Masayuki, Kowalczyk, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235416/
https://ncbi.nlm.nih.gov/pubmed/21160493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.389
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