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Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and can be Reversed by Expression of Exogenous Dsg3

Pemphigus vulgaris (PV) is an epidermal blistering disorder caused by antibodies directed against the desmosomal cadherin desmoglein-3 (Dsg3). The mechanism by which PV IgG disrupt adhesion is not fully understood. To address this issue, primary human keratinocytes and patient IgG were utilized to d...

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Bibliographische Detailangaben
Hauptverfasser: Jennings, Jean Marie, Tucker, Dana K., Kottke, Margaret D., Saito, Masataka, Delva, Emmanuella, Hanakawa, Yasushi, Amagai, Masayuki, Kowalczyk, Andrew P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235416/
https://ncbi.nlm.nih.gov/pubmed/21160493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.389
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