Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression

Hepatic peroxisomes are essential for lipid conversions that include the formation of mature conjugated bile acids, the degradation of branched chain fatty acids, and the synthesis of docosahexaenoic acid. Through unresolved mechanisms, deletion of functional peroxisomes from mouse hepatocytes (L-Pe...

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Main Authors: Peeters, Annelies, Fraisl, Peter, van den Berg, Sjoerd, Ver Loren van Themaat, Emiel, Van Kampen, Antoine, Rider, Mark H., Takemori, Hiroshi, van Dijk, Ko Willems, Van Veldhoven, Paul P., Carmeliet, Peter, Baes, Myriam
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234943/
https://ncbi.nlm.nih.gov/pubmed/22002056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.299727
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