Transcriptional Repression of the α7 Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) by Activating Protein-2α (AP-2α)

The CHRNA7 gene, which encodes the α7 nicotinic acetylcholine receptor (α7*nAChR), has been implicated as a candidate gene in schizophrenia. Expression of the α7*nAChR mRNA and protein are reduced in multiple regions of post-mortem brain from patients diagnosed with schizophrenia. Transcriptional re...

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Bibliografiske detaljer
Main Authors: Finlay-Schultz, Jessica, Canastar, Andrew, Short, Margaret, El Gazzar, Mohamed, Coughlan, Christina, Leonard, Sherry
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234925/
https://ncbi.nlm.nih.gov/pubmed/21979958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276014
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