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Fatty Acids Suppress Autophagic Turnover in β-Cells

Recent studies have shown that autophagy is essential for proper β-cell function and survival. However, it is yet unclear under what pathogenic conditions autophagy is inhibited in β-cells. Here, we report that long term exposure to fatty acids and glucose block autophagic flux in β-cells, contribut...

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Detalhes bibliográficos
Main Authors: Las, Guy, Serada, Sam B., Wikstrom, Jakob D., Twig, Gilad, Shirihai, Orian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234912/
https://ncbi.nlm.nih.gov/pubmed/21859708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242412
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