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Interaction of β(2)-Glycoprotein I with Lipopolysaccharide Leads to Toll-like Receptor 4 (TLR4)-dependent Activation of Macrophages

β(2)-Glycoprotein I (β(2)GPI) is an abundant plasma protein that binds to the surface of cells and particles expressing negatively charged lipids, but its physiological role remains unknown. Antibodies to β(2)GPI are found in patients with anti-phospholipid syndrome, a systemic autoimmune disease as...

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Auteurs principaux: Laplante, Patrick, Amireault, Pascal, Subang, Rebecca, Dieudé, Mélanie, Levine, Jerrold S., Rauch, Joyce
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234909/
https://ncbi.nlm.nih.gov/pubmed/21965665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230383
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