Interaction of β(2)-Glycoprotein I with Lipopolysaccharide Leads to Toll-like Receptor 4 (TLR4)-dependent Activation of Macrophages

β(2)-Glycoprotein I (β(2)GPI) is an abundant plasma protein that binds to the surface of cells and particles expressing negatively charged lipids, but its physiological role remains unknown. Antibodies to β(2)GPI are found in patients with anti-phospholipid syndrome, a systemic autoimmune disease as...

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Autors principals: Laplante, Patrick, Amireault, Pascal, Subang, Rebecca, Dieudé, Mélanie, Levine, Jerrold S., Rauch, Joyce
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234909/
https://ncbi.nlm.nih.gov/pubmed/21965665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230383
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