Compensatory Regulation of Dopamine after Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection

The tyrosine hydroxylase (TH; EC 1.14.16.2) is a rate-limiting enzyme in the dopamine synthesis and important for the central dopaminergic system, which controls voluntary movements and reward-dependent behaviors. Here, to further explore the regulatory mechanism of dopamine levels by TH in adult mo...

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Detalhes bibliográficos
Main Authors: Tokuoka, Hirofumi, Muramatsu, Shin-ichi, Sumi-Ichinose, Chiho, Sakane, Hiroaki, Kojima, Masayo, Aso, Yoshinori, Nomura, Takahide, Metzger, Daniel, Ichinose, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234829/
https://ncbi.nlm.nih.gov/pubmed/22027820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284729
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