Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most patho...

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Hlavní autoři: Garbers, Christoph, Thaiss, Wolfgang, Jones, Gareth W., Waetzig, Georg H., Lorenzen, Inken, Guilhot, Florence, Lissilaa, Rami, Ferlin, Walter G., Grötzinger, Joachim, Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234812/
https://ncbi.nlm.nih.gov/pubmed/21990364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295758
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