Translocation of Heme Oxygenase-1 to Mitochondria Is a Novel Cytoprotective Mechanism against Non-steroidal Anti-inflammatory Drug-induced Mitochondrial Oxidative Stress, Apoptosis, and Gastric Mucosal Injury

The mechanism of action of heme oxygenase-1 (HO-1) in mitochondrial oxidative stress (MOS)-mediated apoptotic tissue injury was investigated. MOS-mediated gastric mucosal apoptosis and injury were introduced in rat by indomethacin, a non-steroidal anti-inflammatory drug. Here, we report that HO-1 wa...

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Hlavní autoři: Bindu, Samik, Pal, Chinmay, Dey, Sumanta, Goyal, Manish, Alam, Athar, Iqbal, Mohd. Shameel, Dutta, Shubham, Sarkar, Souvik, Kumar, Rahul, Maity, Pallab, Bandyopadhyay, Uday
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234763/
https://ncbi.nlm.nih.gov/pubmed/21908612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.279893
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