In Vitro Downregulation of Matrix Metalloproteinase-9 in Rat Glial Cells by CCR5 Antagonist Maraviroc: Therapeutic Implication for HIV Brain Infection

BACKGROUND: Matrix metalloproteinases (MMPs) released by glial cells are important mediators of neuroinflammation and neurologic damage in HIV infection. The use of antiretroviral drugs able to combat the detrimental effect of chronic inflammation and target the exaggerated MMP activity might repres...

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Detalhes bibliográficos
Main Authors: Gramegna, Pasqua, Latronico, Tiziana, Branà, Maria Teresa, Di Bari, Gaetano, Mengoni, Fabio, Belvisi, Valeria, Mascellino, Maria T., Lichtner, Miriam, Vullo, Vincenzo, Mastroianni, Claudio M., Liuzzi, Grazia M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234279/
https://ncbi.nlm.nih.gov/pubmed/22174822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028499
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