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TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis
The cold-sensing channel transient receptor potential melastatin 8 (TRPM8) features Ca(2+)-dependent downregulation, a cellular process underlying somatosensory accommodation in cold environments. The Ca(2+)-dependent functional downregulation of TRPM8 is manifested with two distinctive phases, acut...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234095/ https://ncbi.nlm.nih.gov/pubmed/21900509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00544.2011 |
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