TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis

The cold-sensing channel transient receptor potential melastatin 8 (TRPM8) features Ca(2+)-dependent downregulation, a cellular process underlying somatosensory accommodation in cold environments. The Ca(2+)-dependent functional downregulation of TRPM8 is manifested with two distinctive phases, acut...

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Bibliografiske detaljer
Main Authors: Sarria, Ignacio, Ling, Jennifer, Zhu, Michael X., Gu, Jianguo G.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234095/
https://ncbi.nlm.nih.gov/pubmed/21900509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00544.2011
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