Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK

Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknow...

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Главные авторы: Hitomi, Hirofumi, Mehta, Puja K., Taniyama, Yoshihiro, Lassègue, Bernard, Seidel-Rogol, Bonnie, San Martin, Alejandra, Griendling, Kathy K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2011
Предметы:
Receptors and Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233803/
https://ncbi.nlm.nih.gov/pubmed/21900690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00017.2011
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