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Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

The membrane-bound acetylcholine receptor from Torpedo marmorata was photolabeled by the noncompetitive channel blocker [3H]chlorpromazine under equilibrium conditions in the presence of agonist. Incorporation of radioactivity into all subunits occurred and was reduced by addition of phencyclidine,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Giraudat, J, Dennis, M, Heidmann, T, Chang, J Y, Changeux, J P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1986
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323371/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3085104/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2719
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