A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein.

The human heavy chain disease protein BW is an immunoglobulin mu-chain variant whose amino terminus is initiated at the fifth amino acid of the first constant region domain. We cloned and analyzed both rearranged heavy chain alleles from BW leukemic cells to determine the molecular basis for this de...

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Библиографические подробности
Главные авторы: Bakhshi, A, Guglielmi, P, Siebenlist, U, Ravetch, J V, Jensen, J P, Korsmeyer, S J
Формат: Artigo
Язык:Inglês
Опубликовано: 1986
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC323365/
https://ncbi.nlm.nih.gov/pubmed/3085103
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