Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.
A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to more conventional methods. As judged by quantitative in vitro measurements, a monoclonal antibody conjugate prepared via the oligosaccharides re...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1986
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3458222/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2632 |
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