Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.

A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to more conventional methods. As judged by quantitative in vitro measurements, a monoclonal antibody conjugate prepared via the oligosaccharides re...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rodwell, J D, Alvarez, V L, Lee, C, Lopes, A D, Goers, J W, King, H D, Powsner, H J, McKearn, T J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1986
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3458222/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2632
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