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Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo.

Deficiency of the enzyme adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4; ADA) leads to severe combined immunodeficiency, a disorder that potentially could be corrected by gene transfer into hematopoietic cells. We have constructed retroviruses containing human ADA cDNA and a dominant sele...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Williams, D A, Orkin, S H, Mulligan, R C
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1986
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323339/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3458218/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2566
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