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Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity
α-Gal glycolipids capable of converting tumors into endogenous vaccines, have α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R) and are extracted from rabbit RBC membranes. α-Gal epitopes bind anti-Gal, the most abundant natural antibody in humans constituting 1% of immunoglobulins. α-Gal glycolipids insert i...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233201/ https://ncbi.nlm.nih.gov/pubmed/19184002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-009-0662-2 |
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