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Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity

α-Gal glycolipids capable of converting tumors into endogenous vaccines, have α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R) and are extracted from rabbit RBC membranes. α-Gal epitopes bind anti-Gal, the most abundant natural antibody in humans constituting 1% of immunoglobulins. α-Gal glycolipids insert i...

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Autores principales: Abdel-Motal, Ussama M., Wigglesworth, Kim, Galili, Uri
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233201/
https://ncbi.nlm.nih.gov/pubmed/19184002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-009-0662-2
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