VPg-Primed RNA Synthesis of Norovirus RNA-Dependent RNA Polymerases by Using a Novel Cell-Based Assay

Molecular studies of human noroviruses (NoV) have been hampered by the lack of a permissive cell culture system. We have developed a sensitive and reliable mammalian cell-based assay for the human NoV GII.4 strain RNA-dependent RNA polymerase (RdRp). The assay is based on the finding that RNAs synth...

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Detalhes bibliográficos
Main Authors: Subba-Reddy, Chennareddy V., Goodfellow, Ian, Kao, C. Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233154/
https://ncbi.nlm.nih.gov/pubmed/21994457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06191-11
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