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MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia
Expression of vascular endothelial growth factor (VEGF) increases in cancer cells during hypoxia. Herein, we report that the MDM2 oncoprotein plays a role in hypoxia-mediated VEGF upregulation. In studying the characteristics of MDM2 and VEGF expression in neuroblastoma cells, we found that hypoxia...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233029/ https://ncbi.nlm.nih.gov/pubmed/21986500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06085-11 |
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