Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC

Aberrant MYC expression is a common oncogenic event in human cancer. Paradoxically, MYC can either drive cell cycle progression or induce apoptosis. The latent ability of MYC to induce apoptosis has been termed “intrinsic tumor suppressor activity,” and reactivating this apoptotic function in tumors...

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Main Authors: Zhang, Xiao-Yong, Pfeiffer, Harla K., Mellert, Hestia S., Stanek, Timothy J., Sussman, Robyn T., Kumari, Alpana, Yu, Duonan, Rigoutsos, Isidore, Thomas-Tikhonenko, Andrei, Seidel, Hans E., Chodosh, Lewis A., Packham, Graham, Baserga, Renato, McMahon, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233020/
https://ncbi.nlm.nih.gov/pubmed/21986497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06297-11
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