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Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin
Insulin exerts many of its metabolic actions via the canonical phosphatidylinositide 3 kinase (PI3K)/Akt pathway, leading to phosphorylation and 14-3-3 binding of key metabolic targets. We previously identified a GTPase-activating protein (GAP) for Rac1 called RhoGAP22 as an insulin-responsive 14-3-...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232915/ https://ncbi.nlm.nih.gov/pubmed/21969604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05583-11 |
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