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Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin

Insulin exerts many of its metabolic actions via the canonical phosphatidylinositide 3 kinase (PI3K)/Akt pathway, leading to phosphorylation and 14-3-3 binding of key metabolic targets. We previously identified a GTPase-activating protein (GAP) for Rac1 called RhoGAP22 as an insulin-responsive 14-3-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rowland, Alexander F., Larance, Mark, Hughes, William E., James, David E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232915/
https://ncbi.nlm.nih.gov/pubmed/21969604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05583-11
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