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Homodimerization and Binding of Specific Domains to the Target DNA Are Essential Requirements for HlyU To Regulate Expression of the Virulence Gene rtxA1, Encoding the Repeat-in-Toxin Protein in the Human Pathogen Vibrio vulnificus
The virulence gene rtxA1, encoding the repeat-in-toxin protein, plays an essential role in the pathogenesis of Vibrio vulnificus infections. Expression of this gene is controlled by the HlyU regulator by direct contact of the DNA upstream of the rtxA1 toxin operon acting as a derepressor of the H-NS...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232850/ https://ncbi.nlm.nih.gov/pubmed/22020641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05950-11 |
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