Homodimerization and Binding of Specific Domains to the Target DNA Are Essential Requirements for HlyU To Regulate Expression of the Virulence Gene rtxA1, Encoding the Repeat-in-Toxin Protein in the Human Pathogen Vibrio vulnificus

The virulence gene rtxA1, encoding the repeat-in-toxin protein, plays an essential role in the pathogenesis of Vibrio vulnificus infections. Expression of this gene is controlled by the HlyU regulator by direct contact of the DNA upstream of the rtxA1 toxin operon acting as a derepressor of the H-NS...

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Bibliographic Details
Main Authors: Liu, Moqing, Rose, Michael, Crosa, Jorge H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Molecular Biology of Pathogens
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232850/
https://ncbi.nlm.nih.gov/pubmed/22020641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05950-11
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