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Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

Human endothelial cells in culture produced platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with leukotriene C4 or D4 (LTC4 or LTD4). Other arachidonate metabolites did not induce the synthesis of PAF. Accumulation of PAF was a prolonged response with...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: McIntyre, T M, Zimmerman, G A, Prescott, S M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323260/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3457383/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.7.2204
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