Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha.

Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Modur, V, Li, Y, Zimmerman, G A, Prescott, S M, McIntyre, T M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508479/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9389739/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119821
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