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Chemoprevention of Colon and Small Intestinal Tumorigenesis in APC(Min/+) mice by Licofelone, A Novel Dual 5-LOX/COX Inhibitor: Potential Implications for Human Colon Cancer Prevention

Preclinical and clinical studies suggest that 5-lipoxygenase (5-LOX), like cyclo-oxygenase-2 (COX-2), is a potential target for colon cancer inhibition and, in part, contributes to cardiovascular side effects associated with COX-2 inhibitors. Experiments were designed to assess the chemopreventive e...

詳細記述

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書誌詳細
主要な著者: Mohammed, Altaf, Janakiram, Naveena B., Li, Qian, Choi, Chang-In, Zhang, Yuting, Steele, Vernon E., Rao, Chinthalapally V.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232346/
https://ncbi.nlm.nih.gov/pubmed/21885812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0233
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