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Chemoprevention of Colon and Small Intestinal Tumorigenesis in APC(Min/+) mice by Licofelone, A Novel Dual 5-LOX/COX Inhibitor: Potential Implications for Human Colon Cancer Prevention
Preclinical and clinical studies suggest that 5-lipoxygenase (5-LOX), like cyclo-oxygenase-2 (COX-2), is a potential target for colon cancer inhibition and, in part, contributes to cardiovascular side effects associated with COX-2 inhibitors. Experiments were designed to assess the chemopreventive e...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232346/ https://ncbi.nlm.nih.gov/pubmed/21885812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0233 |
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