Bortezomib Enhances the Efficacy of Fulvestrant by Amplifying the Aggregation of the Estrogen Receptor, Which Leads to a Proapoptotic Unfolded Protein Response

PURPOSE: Fulvestrant is known to promote the degradation of the estrogen receptor (ER) in the nucleus. However, fulvestrant also promotes the aggregation of the newly synthesized ER in the cytoplasm. Accumulation of protein aggregates leads to cell death but this effect is limited as a result of the...

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Hlavní autoři: Ishii, Yuki, Papa, Luena, Bahadur, Urvashi, Yue, Zhenyu, Aguirre-Ghiso, Julio, Shioda, Toshi, Waxman, Samuel, Germain, Doris
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232249/
https://ncbi.nlm.nih.gov/pubmed/21292820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1745
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