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Ectopic Proliferation Contributes to Retinal Dysplasia in the Juvenile Zebrafish patched2 Mutant Eye
PURPOSE. Patched is a well-studied tumor suppressor and negative regulator of the Hedgehog (Hh) pathway. Earlier work in this laboratory has shown that embryonic zebrafish patched2 (ptc2) mutant retinas possess an expanded ciliary marginal zone (CMZ) and phenotypes similar to those in human patients...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3231842/ https://ncbi.nlm.nih.gov/pubmed/22003118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8033 |
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